eagle-i Jackson State UniversityJackson State University
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Ashton Hamme Laboratory

eagle-i ID

http://jsu.eagle-i.net/i/0000012b-1627-e1df-3984-bcfb80000000

Resource Type

  1. Laboratory

Properties

  1. Resource Description
    Our research focuses on the synthesis of natural occurring compounds that have anti-cancer properties, specifically breast cancer. We also synthesize compounds that are similar to natural products, which are called synthetic analogues, and submit them for biological testing. After we receive the biological profile of the synthetic analogues, we modify the functional groups in hopes of increasing the biological activity of the synthetic analogues. We use the structure activity relationship (SAR) to determine which functional groups are necessary for the biological activity of a particular compound series, and the tolerance of the binding pocket towards molecular size and electronics. Thus far, our molecular targets are isoxazolines and spiroisoxazolines that are similar to the ones found in the naturally occurring compound, 11-deoxyfistularin-3, which is cytotoxic against mcf-7 breast cancer tissue. The isoxazolines and spiroisoxazolines are synthesized through a 1,3-dipolar cycloaddition of functionalized alkenes. A student in our research group will learn about the art of organic synthesis, and the techniques that are used to isolate, purify, and identify organic compounds. These skills will be valuable for a student who is interested in a career in organic synthesis and medicinal chemistry.
  2. Contact
    Hamme, Ashton T., Ph.D.
  3. PI
    Hamme, Ashton T., Ph.D.
  4. Affiliation
    College of Science, Engineering & Technology, Jackson State University
  5. Website(s)
    http://www.jsums.edu/cset/or/bios/hamme_c.htm
 
RDFRDF
 
Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016