Pericardial Fat and Echocardiographic Measures of Cardiac Abnormalities: The Jackson Heart Study.

eagle-i ID

Resource Type

Properties

1. Additional Topic(s)

   Echocardiography

2. Additional Topic(s)

   Obesity

3. Resource Description

   Abstract OBJECTIVE- Pericardial adipose tissue (PAT), a regional fat depot adjacent to the myocardium, may mediate the complex relation between obesity and cardiac left ventricular (LV) abnormalities. We sought to evaluate the association of PAT with echocardiographic measures of LV abnormalities in the Jackson Heart Study (JHS). RESEARCH DESIGN AND METHODS A total of 1,414 African Americans (35% men; mean age 58 years) from the JHS underwent computed tomographic assessment of PAT and abdominal visceral adipose tissue (VAT) from 2007 to 2009 and echocardiography examination between 2000 and 2004. Echocardiographic measures of left atrial (LA) internal diameter, LV mass, LV ejection fraction (LVEF), and E-wave velocity-to-A-wave velocity ratio (E/A ratio) were examined in relation to PAT, VAT, BMI, and waist circumference (WC). RESULTS All adiposity measures were positively correlated with LA diameter and LV mass and negatively correlated with E/A ratio (P = 0.02 to 0.0001) and were not with LVEF (P = 0.36-0.61). In women, per 1-SD increment of PAT, we observed association with higher LV mass (9.0 ± 1.7 gm, P = 0.0001) and LA diameter (1.0 ± 0.1 mm, P = 0.0001). However, the magnitude of the association between PAT and cardiac measures was similar compared with VAT (P = 0.65 [LV mass]; P = 0.26 [LA diameter]) and was smallercompared with BMI (P = 0.002 [LV mass]; P = 0.01 [LA diameter]) and WC (P = 0.009 [LA diameter]). CONCLUSIONS PAT is correlated with echocardiographic measures of cardiac LV abnormalities, but the association is not stronger than other adiposity measures.

4. Contact

   Taylor, Jr., Herman A.

5. PI

   Taylor, Jr., Herman A.

6. Topic

   heart disease

7. Study Population

   1,414 African Americans (35% men; mean age 58 years)

8. Related Publication or Documentation

   Pericardial fat and echocardiographic measures of cardiac abnormalities: the Jackson Heart Study.

9. Funded by

   National Center for Minority Health and Health Disparities

10. Funded by

    National Heart, Lung, and Blood Institute

11. Performed by

    Jackson Heart Study