Cohort study
The relation of diabetes, impaired fasting blood glucose, and insulin resistance to left ventricular structure and function in african americans: The Jackson Heart Study.
Insulin Resistance
Additional Topic(s)
has_subject_area
Echocardiography
Blood glucose metabolism
Abstract
OBJECTIVE We assessed the relation of diabetes and insulin resistance (IR) on left ventricular (LV) structure and function in African Americans. RESEARCH DESIGN AND METHODS Among those receiving echocardiograms in cycle 1 of the Jackson Heart Study, we assessed the sex-specific relation of fasting blood glucose (FBG), diabetes, and IR to LV structure and function, adjusting for age, systolic blood pressure, antihypertensive medications, and BMI. RESULTS Among 2,399 participants, LV mass index (P(women) = 0.0002 and P(men) = 0.02), posterior wall thickness (P(women) = 0.01 and P(men) = 0.05), and interventricular septal wall thickness (P(women) = 0.01) were related to FBG categories. Among those with normal FBG and no diabetes, concentric remodeling and low ejection fraction in women and LV mass index and posterior wall thickness in men were related to IR. CONCLUSIONS In the largest study of its kind in a community-based cohort of African Americans, we found a relation of FBG category and IR to LV structure and function.
Resource Description
resource_description
2,399 participants
Study Population
study population
has_study_population
Related Publication or Documentation
has documentation
has_documentation
The relation of diabetes, impaired fasting blood glucose, and insulin resistance to left ventricular structure and function in African Americans: the Jackson Heart Study.
Topic
has topic
has_topic
heart disease
diabetes mellitus
Performed by
human study performed by
human_study_performed_by
Jackson Heart Study
Contact
has contact
has_contact
Taylor, Jr., Herman A.
PI
has PI
has_PI
Funded by
funded by
funded_by
National Center for Minority Health and Health Disparities
2011-02-09T11:44:51.607-06:00
sgarner (Solomon Garner)
2011-05-18T14:21:47.071-05:00
workflow state
Published
nvasilevsky
Observational study
Human Study
human study
human study
Research project
research project
planned process
planned process
Quantitative human study
process
occurrent
entity