Pericardial adipose tissue, atherosclerosis, and cardiovascular disease risk factors: the Jackson Heart Study.

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1. Additional Topic(s)

   Metabolic Syndrome X

2. Resource Description

   Abstract OBJECTIVE: Pericardial adipose tissue (PAT), a regional fat depot that surrounds the heart, is associated with an unfavorable cardiometabolic risk factor profile. The associations among PAT, cardiometabolic risk factors, and coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) in African American populations have not been explored. RESEARCH DESIGN AND METHODS: A total of 1,414 African Americans (35% men; mean +/- SD age 58 +/- 11 years) drawn from the Jackson Heart Study (JHS) underwent multidetector computed tomography assessment of abdominal visceral adipose tissue (VAT) and PAT between 2007 and 2009. Cardiometabolic risk factors, CAC, and AAC were examined in relation to increments of PAT and VAT. RESULTS: PAT was significantly correlated with BMI, waist circumference, and VAT (r = 0.35, 0.46, and 0.69; all P < 0.0001). PAT (per 1-SD increase) was associated with elevated levels of systolic blood pressure (P < 0.04), fasting glucose, triglycerides, and C-reactive protein and lower levels of HDL (all P values<0.0001). PAT was also associated with metabolic syndrome (odds ratio [OR] 1.89; P < 0.0001), hypertension (1.48; P < 0.0006), and diabetes (1.40; P < 0.04); all associations were diminished after further adjustment for VAT (most P > 0.05). However, the association of PAT with CAC but not with AAC remained significant (OR 1.34 [95% CI 1.10-1.64]; P < 0.004) after multivariable and VAT adjustment. CONCLUSIONS: PAT is significantly correlated with most cardiometabolic risk factors and CAC in the JHS cohort. The results suggest that PAT is an important VAT depot that may exert a local effect on the coronary vasculature.

3. Contact

   Taylor, Jr., Herman A.

4. Topic

   coronary artery disease

5. Topic

   aortic disease

6. Study Population

   1,414 African Americans (35% men; mean +/- SD age 58 +/- 11 years)

7. Related Publication or Documentation

   Pericardial adipose tissue, atherosclerosis, and cardiovascular disease risk factors: the Jackson heart study.

8. Funded by

   National Center for Minority Health and Health Disparities

9. Funded by

   National Heart, Lung, and Blood Institute

10. Performed by

    Jackson Heart Study