eagle-i Jackson State UniversityJackson State University
See it in Search
This page is a preview of the following resource. Continue onto eagle-i search using the button on the right to see the full record.

Pericardial adipose tissue, atherosclerosis, and cardiovascular disease risk factors: the Jackson Heart Study.

eagle-i ID

http://jsu.eagle-i.net/i/0000012e-0c1c-1289-d3a1-177580000000

Resource Type

  1. Cohort study

Properties

  1. Additional Topic(s)
    Metabolic Syndrome X
  2. Resource Description
    Abstract OBJECTIVE: Pericardial adipose tissue (PAT), a regional fat depot that surrounds the heart, is associated with an unfavorable cardiometabolic risk factor profile. The associations among PAT, cardiometabolic risk factors, and coronary artery calcification (CAC) and abdominal aortic artery calcification (AAC) in African American populations have not been explored. RESEARCH DESIGN AND METHODS: A total of 1,414 African Americans (35% men; mean +/- SD age 58 +/- 11 years) drawn from the Jackson Heart Study (JHS) underwent multidetector computed tomography assessment of abdominal visceral adipose tissue (VAT) and PAT between 2007 and 2009. Cardiometabolic risk factors, CAC, and AAC were examined in relation to increments of PAT and VAT. RESULTS: PAT was significantly correlated with BMI, waist circumference, and VAT (r = 0.35, 0.46, and 0.69; all P < 0.0001). PAT (per 1-SD increase) was associated with elevated levels of systolic blood pressure (P < 0.04), fasting glucose, triglycerides, and C-reactive protein and lower levels of HDL (all P values<0.0001). PAT was also associated with metabolic syndrome (odds ratio [OR] 1.89; P < 0.0001), hypertension (1.48; P < 0.0006), and diabetes (1.40; P < 0.04); all associations were diminished after further adjustment for VAT (most P > 0.05). However, the association of PAT with CAC but not with AAC remained significant (OR 1.34 [95% CI 1.10-1.64]; P < 0.004) after multivariable and VAT adjustment. CONCLUSIONS: PAT is significantly correlated with most cardiometabolic risk factors and CAC in the JHS cohort. The results suggest that PAT is an important VAT depot that may exert a local effect on the coronary vasculature.
  3. Contact
    Taylor, Jr., Herman A.
  4. Topic
    coronary artery disease
  5. Topic
    aortic disease
  6. Study Population
    1,414 African Americans (35% men; mean +/- SD age 58 +/- 11 years)
  7. Related Publication or Documentation
    Pericardial adipose tissue, atherosclerosis, and cardiovascular disease risk factors: the Jackson heart study.
  8. Funded by
    National Center for Minority Health and Health Disparities
  9. Funded by
    National Heart, Lung, and Blood Institute
  10. Performed by
    Jackson Heart Study
 
RDFRDF
 
Provenance Metadata About This Resource Record
  1. workflow state
    Published
  2. contributor
    nvasilevsky
  3. created
    2011-02-09T14:29:38.000-06:00
  4. creator
    sgarner (Solomon Garner)
  5. modified
    2011-05-18T12:37:40.256-05:00

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016