Cross-sectional study
Relationships of BMI to cardiovascular risk factors differ by ethnicity.
Obesity
Additional Topic(s)
has_subject_area
Abstract
The burden of cardiovascular risk associated with obesity disproportionately affects African Americans and little is known about ethnic/racial differences in the relationship of obesity to cardiometabolic risk. This report assesses whether obesity is similarly associated with cardiometabolic risk factors in African Americans and whites of European ancestry. Cross-sectional observational data from the Jackson Heart Study (JHS) and the Framingham Heart Study (FHS) were compared. This analysis uses participants aged 35-74 years with BMI >18.5 kg/m(2), and free of prevalent cardiovascular disease (CVD), from the initial JHS clinical examination (2000-2004) and the FHS Offspring (1998-2001) and Third Generation (2002-2005) cohorts. Participants were evaluated for the presence of lipid abnormalities, hypertension, and diabetes. Overall, 4,030 JHS (mean age 54 years, 64% women) and 5,245 FHS (mean age 51 years, 54% women) participants were available for analysis. The prevalence of all risk factors except high triglycerides and low high-density lipoprotein (HDL) was substantially higher in JHS (all P < 0.001) and BMI was associated with increasing prevalence of most CVD risk factors within each race. For diabetes mellitus, hypertension, and low HDL, steeper relationships to BMI were observed in FHS than in JHS (P values <0.001-0.016). There were larger proportional increases in risk factor prevalence with increasing BMI in whites than in African Americans. The higher prevalence rates of cardiometabolic risk factors at nearly all levels of BMI in African Americans, however, suggest that additional factors contribute to the burden of CVD risk in African Americans.
Resource Description
resource_description
4,030 JHS (mean age 54 years, 64% women) and 5,245 FHS (mean age 51 years, 54% women) participants
Study Population
study population
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Related Publication or Documentation
has documentation
has_documentation
Relationships of BMI to cardiovascular risk factors differ by ethnicity.
Topic
has topic
has_topic
cardiovascular system disease
hypertension
diabetes mellitus
Performed by
human study performed by
human_study_performed_by
Jackson Heart Study
Contact
has contact
has_contact
Taylor, Jr., Herman A.
PI
has PI
has_PI
Funded by
funded by
funded_by
National Center for Minority Health and Health Disparities
National Heart, Lung, and Blood Institute
2011-02-09T15:09:09.411-06:00
sgarner (Solomon Garner)
2011-05-18T13:18:40.796-05:00
workflow state
Published
nvasilevsky
Observational study
Human Study
human study
human study
Research project
research project
planned process
planned process
Quantitative human study
process
occurrent
entity