Epidemiological study
epidemiological study
epidemiological study
Leptinemia and its association with stroke and coronary heart disease in the Jackson Heart Study.
Leptinemia
Additional Topic(s)
has_subject_area
Abstract
BACKGROUND: To examine the association of increased plasma leptin concentration with prevalent stroke and coronary heart disease (CHD) and to examine the genetic contributions of leptin to this association in the Jackson Heart Study cohort.
METHODS: A cohort of 5170 participants aged 21-84 years who underwent Exam I during 2000-2004 was analysed. Odds ratios (OR) of prevalent stroke and CHD were calculated using a logistic regression model adjusted for age, smoking, hypertension and waist circumference (WC). Variance component analysis was used to partition the phenotypic variance of leptin into the polygenic and environmental components.
RESULTS: The prevalence of stroke and CHD was 4.04% and 5.85% in women, and 4.88% and 8.92% in men, respectively. Body mass index (BMI) and WC were highly correlated with leptin both in men and women. In multivariate analysis stratified by sex, leptin was significantly associated with stroke (OR = 1.97, 95% CI = 1.21-3.21) in women after adjustment for age, smoking, systolic blood pressure, BMI and WC (P = 0.0079). No significant association was observed in men. Heritability of sex-, age-adjusted log-transformed leptin for this cohort was 38.0% and 37.8% after further adjustment for WC and hypertension, respectively. In addition, a sibship effect was also found to be significant and explained 12.2% of the total variance of leptin (P = 0.007).
CONCLUSION: There is a significant association of leptin with stroke in women, which is partly influenced by the genetic factor. The findings suggest that leptinemia is an independent risk factor for stroke in African American women.
Resource Description
resource_description
5,301 participants
Study Population
study population
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Related Publication or Documentation
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Leptinemia and its association with stroke and coronary heart disease in the Jackson Heart Study.
Topic
has topic
has_topic
cerebrovascular disease
coronary artery disease
Performed by
human study performed by
human_study_performed_by
Jackson Heart Study
Contact
has contact
has_contact
Taylor, Jr., Herman A.
PI
has PI
has_PI
Funded by
funded by
funded_by
National Heart, Lung, and Blood Institute
2011-02-09T15:26:54.439-06:00
sgarner (Solomon Garner)
2012-02-27T13:51:15.271-06:00
workflow state
Published
mwilson (Melanie Wilson)
shoffmann
Human Study
human study
human study
Research project
research project
planned process
planned process
process
occurrent
entity