Case-control study
Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene..
Single Nucleotide Polymorphism
Additional Topic(s)
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Duffy Blood-Group System
Abstract
Persistently low white blood cell count (WBC) and neutrophil count is a well-described phenomenon in persons of African ancestry, whose etiology remains unknown. We recently used admixture mapping to identify an approximately 1-megabase region on chromosome 1, where ancestry status (African or European) almost entirely accounted for the difference in WBC between African Americans and European Americans. To identify the specific genetic change responsible for this association, we analyzed genotype and phenotype data from 6,005 African Americans from the Jackson Heart Study (JHS), the Health, Aging and Body Composition (Health ABC) Study, and the Atherosclerosis Risk in Communities (ARIC) Study. We demonstrate that the causal variant must be at least 91% different in frequency between West Africans and European Americans. An excellent candidate is the Duffy Null polymorphism (SNP rs2814778 at chromosome 1q23.2), which is the only polymorphism in the region known to be so differentiated in frequency and is already known to protect against
Resource Description
resource_description
6,005 African American samples from three cohort studies: the Jackson Heart Study (JHS), the Atherosclerotic Risk in Communities (ARIC) Study, and the Health, Aging and Body Composition (Health ABC) Study
Study Population
study population
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Related Publication or Documentation
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Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.
Performed by
human study performed by
human_study_performed_by
Jackson Heart Study
Contact
has contact
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Taylor, Jr., Herman A.
PI
has PI
has_PI
Funded by
funded by
funded_by
National Center for Minority Health and Health Disparities
National Heart, Lung, and Blood Institute
2011-02-09T15:37:24.364-06:00
sgarner (Solomon Garner)
2011-05-18T13:13:31.835-05:00
workflow state
Published
nvasilevsky
Observational study
Human Study
human study
human study
Research project
research project
planned process
planned process
Quantitative human study
process
occurrent
entity