Cohort study
Distinct component profiles and high risk among African Americans with metabolic syndrome: the Jackson Heart Study.
Abstract
OBJECTIVE: Health of African Americans is seriously threatened by unremitting epidemics of diabetes and cardiovascular disease (CVD). However, the role of metabolic syndrome in the African-American population has not been investigated widely. This study examined the prevalence of metabolic syndrome and assessed its cross-sectional relationship to CVD in the Jackson Heart Study (JHS) cohort.
RESEARCH DESIGN AND METHODS: A total of 5,302 participants aged >or=21 years who were recruited at baseline during 2000-2004 were analyzed for this study. Adjusted odds ratios (ORs) were estimated in a logistic regression analysis for coronary heart disease (CHD) and cerebrovascular disease (CBD) in those with and without coexisting metabolic syndrome. Diabetic participants were excluded.
RESULTS: Among those aged 35-84 years, metabolic syndrome prevalence was 43.3% in women and 32.7% in men. Elevated blood pressure (70.4%), abdominal obesity (64.6%), and low HDL cholesterol (37.2%) were highly prevalent among those with metabolic syndrome. Prevalence rates for CVD, CHD, and CBD were 12.8, 8.7, and 5.8%, respectively. After adjustment for age and sex, metabolic syndrome was associated with increased age- and sex-adjusted ORs for CVD (OR 1.7 [95% CI 1.4-2.1]), CHD (1.7 [1.4-2.2]), and CBD (1.7 [1.3-2.3]) compared with those without CVD, CHD, or CBD.
CONCLUSION: Metabolic syndrome prevalence in the JHS is among the highest reported for population-based cohorts worldwide and is significantly associated with increased ORs for CVD, CHD, and CBD. Abdominal obesity, increased blood pressure, and low HDL cholesterol (without triglyceride elevation) are surprisingly prominent. A high prevalence of low HDL emerges as a leading contributor to metabolic syndrome among African Americans in this large African-American cohort.
Resource Description
resource_description
5,302 participants aged >or=21 years
Study Population
study population
has_study_population
Related Publication or Documentation
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has_documentation
Distinct component profiles and high risk among African Americans with metabolic syndrome: the Jackson Heart Study.
Topic
has topic
has_topic
cardiovascular system disease
diabetes mellitus
coronary artery disease
obesity
metabolic syndrome X
Performed by
human study performed by
human_study_performed_by
Jackson Heart Study
Contact
has contact
has_contact
Taylor, Jr., Herman A.
PI
has PI
has_PI
Funded by
funded by
funded_by
National Heart, Lung, and Blood Institute
2011-02-09T16:15:09.984-06:00
sgarner (Solomon Garner)
2011-05-20T12:55:03.703-05:00
workflow state
Published
nvasilevsky
Observational study
Human Study
human study
human study
Research project
research project
planned process
planned process
Quantitative human study
process
occurrent
entity