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Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies.

eagle-i ID

http://jsu.eagle-i.net/i/0000012e-0c8a-1228-d3a1-177580000000

Resource Type

  1. Epidemiological study

Properties

  1. Additional Topic(s)
    Admixture mapping
  2. Additional Topic(s)
    Chromosome 1q
  3. Additional Topic(s)
    White blood cell count
  4. Resource Description
    "White blood cell count (WBC) is an important clinical marker that varies among different ethnic groups. African Americans are known to have a lower WBC than European Americans. We surveyed the entire genome for loci underlying this difference in WBC by using admixture mapping. We analyzed data from African American participants in the Health, Aging, and Body Composition Study and the Jackson Heart Study. Participants of both studies were genotyped across >or= 1322 single nucleotide polymorphisms that were pre-selected to be informative for African versus European ancestry and span the entire genome. We used these markers to estimate genetic ancestry in each chromosomal region and then tested the association between WBC and genetic ancestry at each locus. We found a locus on chromosome 1q strongly associated with WBC (p < 10(-12)). The strongest association was with a marker known to affect the expression of the Duffy blood group antigen. Participants who had both copies of the common West African allele had a mean WBC of 4.9 (SD 1.3); participants who had both common European alleles had a mean WBC of 7.1 (SD 1.3). This variant explained approximately 20% of population variation in WBC. We used admixture mapping, a novel method for conducting genetic-association studies, to find a region that was significantly associated with WBC on chromosome 1q. Additional studies are needed to determine the biological mechanism for this effect and its clinical implications."
  5. Contact
    Taylor, Jr., Herman A.
  6. PI
    Taylor, Jr., Herman A.
  7. Topic
    hematopoietic system disease
  8. Study Population
    African American participants in the Health, Aging, and Body Composition Study and the Jackson Heart Study
  9. Related Publication or Documentation
    Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies
  10. Website(s)
    https://www.jacksonheartstudy.org/jhsinfo/
  11. Funded by
    National Center for Minority Health and Health Disparities
  12. Funded by
    National Heart, Lung, and Blood Institute
  13. Funded by
    National Institute on Aging
  14. Performed by
    Jackson Heart Study
 
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Provenance Metadata About This Resource Record

Copyright © 2016 by the President and Fellows of Harvard College
The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016