Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies.

eagle-i ID

Resource Type

Properties

1. Additional Topic(s)

   Admixture mapping

2. Additional Topic(s)

   Chromosome 1q

3. Additional Topic(s)

   White blood cell count

4. Resource Description

   "White blood cell count (WBC) is an important clinical marker that varies among different ethnic groups. African Americans are known to have a lower WBC than European Americans. We surveyed the entire genome for loci underlying this difference in WBC by using admixture mapping. We analyzed data from African American participants in the Health, Aging, and Body Composition Study and the Jackson Heart Study. Participants of both studies were genotyped across >or= 1322 single nucleotide polymorphisms that were pre-selected to be informative for African versus European ancestry and span the entire genome. We used these markers to estimate genetic ancestry in each chromosomal region and then tested the association between WBC and genetic ancestry at each locus. We found a locus on chromosome 1q strongly associated with WBC (p < 10(-12)). The strongest association was with a marker known to affect the expression of the Duffy blood group antigen. Participants who had both copies of the common West African allele had a mean WBC of 4.9 (SD 1.3); participants who had both common European alleles had a mean WBC of 7.1 (SD 1.3). This variant explained approximately 20% of population variation in WBC. We used admixture mapping, a novel method for conducting genetic-association studies, to find a region that was significantly associated with WBC on chromosome 1q. Additional studies are needed to determine the biological mechanism for this effect and its clinical implications."

5. Contact

   Taylor, Jr., Herman A.

6. PI

   Taylor, Jr., Herman A.

7. Topic

   hematopoietic system disease

8. Study Population

   African American participants in the Health, Aging, and Body Composition Study and the Jackson Heart Study

9. Related Publication or Documentation

   Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies

10. Website(s)

    https://www.jacksonheartstudy.org/jhsinfo/

11. Funded by

    National Center for Minority Health and Health Disparities

12. Funded by

    National Heart, Lung, and Blood Institute

13. Funded by

    National Institute on Aging

14. Performed by

    Jackson Heart Study