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Left ventricular geometric patterns in the Jackson cohort of the Atherosclerotic Risk in Communities (ARIC) Study: clinical correlates and influences on systolic and diastolic dysfunction.

eagle-i ID

http://jsu.eagle-i.net/i/0000012e-0c99-aa4f-d3a1-177580000000

Resource Type

  1. Cohort study

Properties

  1. Additional Topic(s)
    Myocardial Contraction
  2. Additional Topic(s)
    left ventricle pathology
  3. Resource Description
    Abstract BACKGROUND: The distribution and determinants of left ventricular (LV) geometric patterns and their relation to LV function in African Americans is not well described despite higher rates of LV hypertrophy and cardiovascular mortality reported in this group. PURPOSE: This study investigates the distribution and clinical correlates of LV geometric patterns and how these patterns relate to function in a population-based African American cohort. METHODS: The study population included participants in the Jackson cohort of ARIC, who underwent echocardiograms between 1993 and 1995. We defined 4 geometric patterns (normal geometry, concentric remodeling [CR], eccentric hypertrophy [EH], and concentric hypertrophy [CH]) according to LV mass index and relative wall thickness. Multiple logistic regression was used to assess the association of geometric patterns to systolic dysfunction and diastolic dysfunction, adjusting for traditional coronary risk factors. RESULTS: There were 1849 participants in the study population (mean age 59 years, 65% women). Concentric remodeling and CH were highly prevalent. Concentric hypertrophy and EH groups had the highest rates of hypertension, obesity, and diabetes mellitus. Compared to the normal geometric pattern, EH was related to systolic dysfunction (OR 24.27, CI 6.71-87.80), and CH was related to diastolic dysfunction 1.58 (1.04-2.39). Concentric remodeling was not related to systolic or diastolic dysfunction. CONCLUSION: In this large middle-aged African American cohort, CR and CH are prevalent. Hypertension, diabetes mellitus, and obesity are associated with both CH and EH. Concentric hypertrophy is strongly associated with diastolic dysfunction; EH is strongly associated with systolic dysfunction. Concentric remodeling, however, is not related to either systolic or diastolic dysfunction.
  4. Contact
    Taylor, Jr., Herman A.
  5. PI
    Taylor, Jr., Herman A.
  6. Topic
    atherosclerosis
  7. Study Population
    1,849 participants (mean age 59 years, 65% women)
  8. Related Publication or Documentation
    Left ventricular geometric patterns in the Jackson cohort of the Atherosclerotic Risk in Communities (ARIC) Study: clinical correlates and influences on systolic and diastolic dysfunction.
  9. Funded by
    National Center for Minority Health and Health Disparities
  10. Performed by
    Jackson Heart Study
 
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