Cardiovascular disease event classification in the Jackson Heart Study: methods and procedures.

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1. Resource Description

   Abstract OBJECTIVE: This paper describes the preparation of genetic materials and the recruitment and initial characterization of a nested Family Study within the Jackson Heart Study (JHS) METHODS: Genomic DNA was prepared from all consenting JHS participants. In addition, family members of a subset of JHS participants were recruited to the JHS Family Study to allow heritability and linkage analyses and family-based association studies. Family Study participants completed the same questionnaires, measures, and procedures as all other JHS participants and provided blood samples for lymphocyte cryopreservation and transformation. RESULTS: DNA samples were obtained from 4726 JHS participants, including 1499 members of 291 families. In the family cohort, estimated heritabilities of body mass index, selected lipid levels, and blood pressure are highly significant, supporting the validity of the sample. DISCUSSION: The JHS data and genetic materials (DNA and cryopreserved cells) offer valuable opportunities to identify susceptibility alleles for common complex diseases by positional and candidate gene approaches.

2. Contact

   Taylor, Jr., Herman A.

3. PI

   Taylor, Jr., Herman A.

4. Topic

   cardiovascular system disease

5. Study Population

   4726 Jackson Heart Study participants, including 1499 members of 291 families

6. Related Publication or Documentation

   Cardiovascular disease event classification in the Jackson Heart Study: methods and procedures

7. Performed by

   Jackson Heart Study