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Ashton Hamme Laboratory


Our research focuses on the synthesis of natural occurring compounds that have anti-cancer properties, specifically breast cancer. We also synthesize compounds that are similar to natural products, which are called synthetic analogues, and submit them for biological testing. After we receive the biological profile of the synthetic analogues, we modify the functional groups in hopes of increasing the biological activity of the synthetic analogues. We use the structure activity relationship (SAR) to determine which functional groups are necessary for the biological activity of a particular compound series, and the tolerance of the binding pocket towards molecular size and electronics. Thus far, our molecular targets are isoxazolines and spiroisoxazolines that are similar to the ones found in the naturally occurring compound, 11-deoxyfistularin-3, which is cytotoxic against mcf-7 breast cancer tissue. The isoxazolines and spiroisoxazolines are synthesized through a 1,3-dipolar cycloaddition of functionalized alkenes. A student in our research group will learn about the art of organic synthesis, and the techniques that are used to isolate, purify, and identify organic compounds. These skills will be valuable for a student who is interested in a career in organic synthesis and medicinal chemistry.



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Last updated: 2011-05-19T10:36:30.151-05:00

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The eagle-i Consortium is supported by NIH Grant #5U24RR029825-02 / Copyright 2016