Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene..

eagle-i ID

Resource Type

Properties

1. Additional Topic(s)

   Duffy Blood-Group System

2. Additional Topic(s)

   Single Nucleotide Polymorphism

3. Resource Description

   Abstract Persistently low white blood cell count (WBC) and neutrophil count is a well-described phenomenon in persons of African ancestry, whose etiology remains unknown. We recently used admixture mapping to identify an approximately 1-megabase region on chromosome 1, where ancestry status (African or European) almost entirely accounted for the difference in WBC between African Americans and European Americans. To identify the specific genetic change responsible for this association, we analyzed genotype and phenotype data from 6,005 African Americans from the Jackson Heart Study (JHS), the Health, Aging and Body Composition (Health ABC) Study, and the Atherosclerosis Risk in Communities (ARIC) Study. We demonstrate that the causal variant must be at least 91% different in frequency between West Africans and European Americans. An excellent candidate is the Duffy Null polymorphism (SNP rs2814778 at chromosome 1q23.2), which is the only polymorphism in the region known to be so differentiated in frequency and is already known to protect against

4. Contact

   Taylor, Jr., Herman A.

5. PI

   Taylor, Jr., Herman A.

6. Study Population

   6,005 African American samples from three cohort studies: the Jackson Heart Study (JHS), the Atherosclerotic Risk in Communities (ARIC) Study, and the Health, Aging and Body Composition (Health ABC) Study

7. Related Publication or Documentation

   Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.

8. Funded by

   National Center for Minority Health and Health Disparities

9. Funded by

   National Heart, Lung, and Blood Institute

10. Performed by

    Jackson Heart Study